Tumor Hypoxia
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Book Overview Tumors often start out as a benign growth, but gradually progress toward the malignant stage over a relatively long period of time. Tumor...
Tumors often start out as a benign growth, but gradually progress toward the malignant stage over a relatively long period of time. Tumor progression results from accumulated genetic mutations and inheritable epigenetic modifications that enable clonal evolution and selection of new clonal populations of tumor cells with aggressive characteristics including metastasis and therapy resistance. Increasing amounts of experimental evidence suggests that tumor microenvironment play a significant role in directing clonal evolution and determining clonal cell fate, which eventually leads to emergence of malignant tumor cell clones. Hypoxia is the most commonly observed feature of tumor microenvironment. Tumor hypoxia is significantly associated with malignant progression and predicts poor patient outcomes. This book provides detailed and up-to-date treaties on the role of hypoxia as a major driving force in tumor microenvironment to elicit cellular adaptation and clonal selection via genetic mutations and epigenetic modifications, to facilitate cancer stem cell maintenance, to enhance metastasis, to augment therapy resistance, and to evade immune surveillance.
Book Details Format: Hardcover | Pages: 306 | Language: English | Publisher: WORLD SCIENTIFIC PUB CO INC | ISBN: 9813147318
FormatHardcover
Pages306
LanguageEnglish
ISBN9813147318
EAN9789813147317
PublisherWORLD SCIENTIFIC PUB CO INC
Publication Date1970-01-01
AccessoriesNo Accessory
ConditionNew
Product TypeHARD COVER BOOKS
Weight1.45 Pounds
Length9.1 Inches
Width6.1 Inches
Height0.8 Inches
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