Protein Folding Disorders of the Central Nervous System
Regular price
$165.41 USD
Regular price
$183.79 USD
Sale price
$165.41 USD
Unit price
per
You save $18.38 USD (10%)
In stock — Ships within 1–2 business days
Format
Print Book
Currently viewing
Hardcover
$165.41 USD
$183.79 USD
Secure CheckoutYour data is protected
Fast U.S. ShippingShips within 1–2 business days
Authentic Titles100% Genuine Books
Book Overview This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostat...
This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements.
This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases.
Book Details Format: Hardcover | Pages: 313 | Language: English | Publisher: WORLD SCIENTIFIC PUB CO INC | ISBN: 9813222956
FormatHardcover
Pages313
LanguageEnglish
ISBN9813222956
EAN9789813222953
PublisherWORLD SCIENTIFIC PUB CO INC
Publication Date1970-01-01
Edition1
AccessoriesNo Accessory
ConditionNew
Product TypeHARD COVER BOOKS
Weight1.35 Pounds
Length9.0 Inches
Width6.0 Inches
Height0.75 Inches
Shipping & Returns Fast, reliable shipping and easy returns on eligible items.
Most orders ship within 1–2 business days with fast, reliable U.S. delivery.
Eligible items can be returned within 30 days in line with our store return policy.
Why shop with AlbakiReads
Fresh Inventory from Major Publishers
Sourced through trusted book distributors, with fresh titles added regularly.
Secure Checkout
Your payment information is encrypted and protected every step of the way.
Fast U.S. Shipping
Most orders ship within 1–2 business days.
Books for Every Kind of Reader
From page-turners to timeless classics—find your next favorite read.
