This book describes the state-of-the-art in ontology-driven information systems (ODIS) and gives a complete perspective on the problems, solutions and open research questions in this field. The book is a compilation of 32 leading-edge chapter contributions from some of the top researchers in the community working in various fundamental and applied disciplines related to ODIS. It covers four broad areas: foundations of ODIS, ontological engineering, ODIS architectures, and ODIS applications. This book will trigger innovative thought processes and open up significant new domains in ODIS research. Numerous open research questions, challenges and opportunities can be found throughout this book and we hope this will stimulate significant research over the years.