This book constitutes the proceedings of the 15th International Conference on Integration of Artificial Intelligence and Operations Research Techniques in Constraint Programming for Combinatorial Optimization Problems, CPAIOR 2018, held in Delft, The Netherlands, in June 2018.

The 47 full papers presented together with 3 abstracts of invited talks and 3 abstracts of fast-track journal papers were carefully reviewed and selected from 111 submissions. The conference brings together interested researchers from constraint programming, artificial intelligence, and operations research to present new techniques or applications in the intersection of these fields and provides an opportunity for researchers in one area to learn about techniques in the others, and to show how the integration of techniques from different fields can lead to interesting results on large and complex problems.