The management of acute coronary syndrome with ST-segment elevation (STEMI) is still a problem in regions outside our country's major metropolises.The aim of our study is to demonstrate the value of setting up a thrombolysis network for STEMI patients in the Mostaganem region.Methods: Single-center prospective observational study, conducted from December 1, 2018 to November 30, 2022.A descriptive analysis was performed on the characteristics, management and intra-hospital prognosis of these patients.Results: From the 10 STEMI patients who underwent thrombolysis during one year before the installation of this network, we increased to an average of 74 patients thrombolysed per year within the framework of the thrombolysis network at the Mostaganem level. We included 295 patients with an average age of 58 years, predominantly male (83.7%). The average pain-reperfusion time was 3 hours 42 minutes (2 hours 48 minutes for the city of Mostaganem vs. 4 hours 21 minutes for its outskirts; p