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Its principles are straightforward: they are aimed at protecting those subjects that participate in the trial, and their goal is to provide reliable data that will contribute to the safety and efficacy of the intervention under study, i.e. to support the health of future subjects. However, the practical implementation of these major goals is complicated. Various mishaps have happened in recent history, and an extensive set of international rules and regulations have emerged.\u003c\/p\u003e\u003cp\u003eThis book gives a thorough survey of the ethical and legal aspects of clinical research and provides a detailed guideline for implementing these aspects into the practice of studying investigational medicinal products in humans, in the European context. 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Each chapter methodically uncovers the disturbing details of these studies, analyzing the impact on the victims and the long-term effects on public trust and medical ethics.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eBy providing a critical examination of the ethical breaches in historical medical research, this book emphasizes the importance of informed consent, the protection of vulnerable populations, and the need for stringent ethical standards in medical studies. 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Drawing on decades of research into end-of-life phenomena and over 25 years of experience providing spiritual care to cancer and palliative patients, Maginley illuminates the inner dimensions of dying and how to address the distress that drives MAiD requests. With compelling research, personal stories, and profound spiritual insights, Early Exits reframes dying as a transformative process that leads us beyond grief and despair to a state of grace and growth.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCentral topics explored: \u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eWhy existential suffering-not physical pain-is at the heart of requests for assisted death, and how to best address it.\u003c\/li\u003e\n\u003cli\u003eHow the deconstruction of identity accelerates spiritual growth and calibrates us for transcendence.\u003c\/li\u003e\n\u003cli\u003eThe importance of addressing both physical and psycho-spiritual needs in palliative care.\u003c\/li\u003e\n\u003cli\u003eHow MAiD compromises the mystical, expansive states of consciousness experienced by most dying people, regardless of culture or belief.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eMaginley's insights are shaped not only by decades of experience supporting those facing mortality but also by his own journey as a four-time cancer survivor. 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